Pre-main sequence accretion in the low metallicity Galactic star-forming region Sh 2-284

We present optical spectra of pre-main sequence (PMS) candidates around the H$\alpha$ region taken with the Southern African Large Telescope, SALT, in the low metallicity ($Z$) Galactic region Sh 2-284, which includes the open cluster Dolidze 25 with an atypical low metallicity of $Z$ $\sim$ 1/5 $Z_{\odot}$. It has been suggested on the basis of both theory and observations that PMS mass-accretion rates, $\dot M_{\rm{acc}}$, are a function of $Z$. We present the first sample of spectroscopic estimates of mass-accretion rates for PMS stars in any low-$Z$ star-forming region. Our data-set was enlarged with literature data of H$\alpha$ emission in intermediate-resolution R-band spectroscopy. Our total sample includes 24 objects spanning a mass range between 1 - 2 $M_{\odot}$ and with a median age of approximately 3.5 Myr. The vast majority (21 out of 24) show evidence for a circumstellar disk on the basis of 2MASS and Spitzer infrared photometry. We find $\dot M_{\rm{acc}}$ in the 1 - 2 $M_{\odot}$ interval to depend quasi-quadratically on stellar mass, with $\dot M_{\rm{acc}}$ $\propto$ $M_{\ast}^{2.4\,\pm\,0.35}$, and inversely with stellar age $\dot M_{\rm{acc}}$ $\propto$ $t_{\ast}^{-\,0.7\,\pm\,0.4}$. Furthermore, we compare our spectroscopic $\dot M_{\rm{acc}}$ measurements with solar $Z$ Galactic PMS stars in the same mass range, but, surprisingly find no evidence for a systematic change in $\dot M_{\rm{acc}}$ with $Z$. We show that literature accretion-rate studies are influenced by detection limits, and we suggest that $\dot M_{\rm{acc}}$ may be controlled by factors other than $Z_{\ast}$, $M_{\ast}$, and age.Comment: Accepted for publication in the Astrophysical Journal. Contains 13 pages, 11 figures, 4 table

The Gaia-ESO Survey: dynamics of ionized and neutral gas in the Lagoon nebula (M8)

We present a spectroscopic study of the dynamics of the ionized and neutral gas throughout the Lagoon nebula (M8), using VLT/FLAMES data from the Gaia-ESO Survey. We explore the connections between the nebular gas and the stellar population of the associated star cluster NGC6530. We characterize through spectral fitting emission lines of H-alpha, [N II] and [S II] doublets, [O III], and absorption lines of sodium D doublet, using data from the FLAMES/Giraffe and UVES spectrographs, on more than 1000 sightlines towards the entire face of the Lagoon nebula. Gas temperatures are derived from line-width comparisons, densities from the [S II] doublet ratio, and ionization parameter from H-alpha/[N II] ratio. Although doubly-peaked emission profiles are rarely found, line asymmetries often imply multiple velocity components along the line of sight. This is especially true for the sodium absorption, and for the [O III] lines. Spatial maps for density and ionization are derived, and compared to other known properties of the nebula and of its massive stars 9 Sgr, Herschel 36 and HD 165052 which are confirmed to provide most of the ionizing flux. The detailed velocity fields across the nebula show several expanding shells, related to the cluster NGC6530, the O stars 9 Sgr and Herschel 36, and the massive protostar M8East-IR. The origins of kinematical expansion and ionization of the NGC6530 shell appear to be different. We are able to put constrains on the line-of-sight (relative or absolute) distances between some of these objects and the molecular cloud. The large obscuring band running through the middle of the nebula is being compressed by both sides, which might explain its enhanced density. We also find an unexplained large-scale velocity gradient across the entire nebula. At larger distances, the transition from ionized to neutral gas is studied using the sodium lines.Comment: 26 pages, 31 figures, accepted on Astronomy and Astrophysics journa

The VLT-FLAMES Tarantula Survey XIX. B-type Supergiants - Atmospheric parameters and nitrogen abundances to investigate the role of binarity and the width of the main sequence

TLUSTY non-LTE model atmosphere calculations have been used to determine atmospheric parameters and nitrogen (N) abundances for 34 single and 18 binary B-type supergiants (BSGs). The effects of flux contribution from an unseen secondary were considered for the binary sample. We present the first systematic study of the incidence of binarity for a sample of BSGs across the theoretical terminal age main sequence (TAMS). To account for the distribution of effective temperatures of the BSGs it may be necessary to extend the TAMS to lower temperatures. This is consistent with the derived distribution of mass discrepancies, projected rotational velocities (vsini) and N abundances, provided that stars cooler than this temperature are post RSG objects. For the BSGs in the Tarantula and previous FLAMES surveys, most have small vsini. About 10% have larger vsini (>100 km/s) but surprisingly these show little or no N enhancement. All the cooler BSGs have low vsini of <70km/s and high N abundance estimates, implying that either bi-stability braking or evolution on a blue loop may be important. A lack of cool binaries, possibly reflects the small sample size. Single star evolutionary models, which include rotation, can account for the N enhancement in both the single and binary samples. The detailed distribution of N abundances in the single and binary samples may be different, possibly reflecting differences in their evolutionary history. The first comparative study of single and binary BSGs has revealed that the main sequence may be significantly wider than previously assumed, extending to Teff=20000K. Some marginal differences in single and binary atmospheric parameters and abundances have been identified, possibly implying non-standard evolution for some of the sample. This sample as a whole has implications for several aspects of our understanding of the evolution of BSGs. Full abstract in paperComment: 21 pages, 15 figures, 11 table

The VLT-FLAMES Tarantula Survey XV. VFTS 822: A candidate Herbig B[e] star at low metallicity

We report the discovery of the B[e] star VFTS 822 in the 30 Doradus star-forming region of the Large Magellanic Cloud, classified by optical spectroscopy from the VLT-FLAMES Tarantula Survey and complementary infrared photometry. VFTS 822 is a relatively low-luminosity (log L = 4.04 ± 0.25 L⊙) B8[e] star. In this Letter, we evaluate the evolutionary status of VFTS 822 and discuss its candidacy as a Herbig B[e] star. If the object is indeed in the pre-main sequence phase, it would present an exciting opportunity to spectroscopically measure mass accretion rates at low metallicity, to probe the effect of metallicity on accretion rates

Deep Sequence Analysis of Non-Small Cell Lung Cancer: Integrated Analysis of Gene Expression, Alternative Splicing, and Single Nucleotide Variations in Lung Adenocarcinomas with and without Oncogenic KRAS Mutations

KRAS mutations are highly prevalent in non-small cell lung cancer (NSCLC), and tumors harboring these mutations tend to be aggressive and resistant to chemotherapy. We used next-generation sequencing technology to identify pathways that are specifically altered in lung tumors harboring a KRAS mutation. Paired-end RNA-sequencing of 15 primary lung adenocarcinoma tumors (8 harboring mutant KRAS and 7 with wild-type KRAS) were performed. Sequences were mapped to the human genome, and genomic features, including differentially expressed genes, alternate splicing isoforms and single nucleotide variants, were determined for tumors with and without KRAS mutation using a variety of computational methods. Network analysis was carried out on genes showing differential expression (374 genes), alternate splicing (259 genes), and SNV-related changes (65 genes) in NSCLC tumors harboring a KRAS mutation. Genes exhibiting two or more connections from the lung adenocarcinoma network were used to carry out integrated pathway analysis. The most significant signaling pathways identified through this analysis were the NFκB, ERK1/2, and AKT pathways. A 27 gene mutant KRAS-specific sub network was extracted based on gene–gene connections from the integrated network, and interrogated for druggable targets. Our results confirm previous evidence that mutant KRAS tumors exhibit activated NFκB, ERK1/2, and AKT pathways and may be preferentially sensitive to target therapeutics toward these pathways. In addition, our analysis indicates novel, previously unappreciated links between mutant KRAS and the TNFR and PPARγ signaling pathways, suggesting that targeted PPARγ antagonists and TNFR inhibitors may be useful therapeutic strategies for treatment of mutant KRAS lung tumors. Our study is the first to integrate genomic features from RNA-Seq data from NSCLC and to define a first draft genomic landscape model that is unique to tumors with oncogenic KRAS mutations

Classical T Tauri stars with VPHAS+ -I : H α and u-band accretion rates in the Lagoon Nebula M8

We estimate the accretion rates of 235 Classical T Tauri star (CTTS) candidates in the Lagoon Nebula using $ugri$H$\alpha$ photometry from the VPHAS+ survey. Our sample consists of stars displaying H$\alpha$-excess, the intensity of which is used to derive accretion rates. For a subset of 87 stars, the intensity of the $u$-band excess is also used to estimate accretion rates. We find the mean variation in accretion rates measured using H$\alpha$ and $u$-band intensities to be $\sim$ 0.17 dex, agreeing with previous estimates (0.04-0.4 dex) but for a much larger sample. The spatial distribution of CTTS align with the location of protostars and molecular gas suggesting that they retain an imprint of the natal gas fragmentation process. Strong accretors are concentrated spatially, while weak accretors are more distributed. Our results do not support the sequential star forming processes suggested in the literature.Peer reviewe

New OB star candidates in the Carina Arm around Westerlund 2 from VPHAS+

Date of Acceptance: 10/04/2015O and early B stars are at the apex of galactic ecology, but in the Milky Way, only a minority of them may yet have been identified. We present the results of a pilot study to select and parametrise OB star candidates in the Southern Galactic plane, down to a limiting magnitude of $g=20$. A 2 square-degree field capturing the Carina Arm around the young massive star cluster, Westerlund 2, is examined. The confirmed OB stars in this cluster are used to validate our identification method, based on selection from the $(u-g, g-r)$ diagram for the region. Our Markov Chain Monte Carlo fitting method combines VPHAS+ $u, g, r, i$ with published $J, H, K$ photometry in order to derive posterior probability distributions of the stellar parameters $\log(\rm T_{\rm eff})$ and distance modulus, together with the reddening parameters $A_0$ and $R_V$. The stellar parameters are sufficient to confirm OB status while the reddening parameters are determined to a precision of $\sigma(A_0)\sim0.09$ and $\sigma(R_V)\sim0.08$. There are 489 objects that fit well as new OB candidates, earlier than $\sim$B2. This total includes 74 probable massive O stars, 5 likely blue supergiants and 32 reddened subdwarfs. This increases the number of previously known and candidate OB stars in the region by nearly a factor of 10. Most of the new objects are likely to be at distances between 3 and 6 kpc. We have confirmed the results of previous studies that, at these longer distances, these sight lines require non-standard reddening laws with $3.5R_VPeer reviewe

A Tale of Three Cities : OmegaCAM discovers multiple sequences in the color-magnitude diagram of the Orion Nebula Cluster

Reproduced with permission from Astronomy & Astrophysics, © 2017 ESO. Published by EDP Sciences.As part of the Accretion Discs in H$\alpha$ with OmegaCAM (ADHOC) survey, we imaged in r, i and H-alpha a region of 12x8 square degrees around the Orion Nebula Cluster. Thanks to the high-quality photometry obtained, we discovered three well-separated pre-main sequences in the color-magnitude diagram. The populations are all concentrated towards the cluster's center. Although several explanations can be invoked to explain these sequences we are left with two competitive, but intriguing, scenarios: a population of unresolved binaries with an exotic mass ratio distribution or three populations with different ages. Independent high-resolution spectroscopy supports the presence of discrete episodes of star formation, each separated by about a million years. The stars from the two putative youngest populations rotate faster than the older ones, in agreement with the evolution of stellar rotation observed in pre-main sequence stars younger than 4 Myr in several star forming regions. Whatever the final explanation, our results prompt for a revised look at the formation mode and early evolution of stars in clusters.Peer reviewedFinal Published versio

The VLT-FLAMES Tarantula Survey XVIII. Classifications and radial velocities of the B-type stars

We present spectral classifications for 438 B-type stars observed as part of the VLT-FLAMES Tarantula Survey (VFTS) in the 30 Doradus region of the Large Magellanic Cloud. Radial velocities are provided for 307 apparently single stars, and for 99 targets with radial-velocity variations which are consistent with them being spectroscopic binaries. We investigate the spatial distribution of the radial velocities across the 30 Dor region, and use the results to identify candidate runaway stars. Excluding potential runaways and members of two older clusters in the survey region (SL 639 and Hodge 301), we determine a systemic velocity for 30 Dor of 271.6 ± 12.2 kms-1 from 273 presumed single stars. Employing a 3σ criterion we identify nine candidate runaway stars (2.9% of the single stars with radial-velocity estimates). The projected rotational velocities of the candidate runaways appear to be significantly different to those of the full B-type sample, with a strong preference for either large (≥345 kms-1) or small (≤65 kms-1) rotational velocities. Of the candidate runaways, VFTS 358 (classified B0.5: V) has the largest differential radial velocity (−106.9 ± 16.2 kms-1), and a preliminary atmospheric analysis finds a significantly enriched nitrogen abundance of 12 + log (N/H) ≳ 8.5. Combined with a large rotational velocity (ve sin i = 345 ± 22 kms-1), this is suggestive of past binary interaction for this star

The Gaia-ESO Survey: Pre-Main Sequence Stars in the Young Open Cluster NGC 3293

The young open cluster NGC3293 is included in the observing program of the Gaia-ESO survey (GES). The radial velocity values provided have been used to assign cluster membership probabilities by means of a single-variable parametric analysis. These membership probabilities are compared to the results of the photometric membership assignment of NGC3293, based on UBV RI photometry. The agreement of the photometric and kinematic member samples amounts to 65%, and could increase to 70% as suggested by the analysis of the differences between both samples. A number of photometric PMS candidate members of spectral type F are found, which are confirmed by the results from VPHAS photometry and SED fitting for the stars in common with VPHAS and GES data sets. Excesses at mid- and near-infrared wavelengths, and signs of Hα emission, are investigated for them. Marginal presence of Hα emission or infilling is detected for the candidate members. Several of them exhibit moderate signs of U excess and weak excesses at mid-IR wavelengths. We suggest that these features originate from accretion disks in their last stages of evolution